Key Takeaways
Potent Formulation
2500FU nattokinase enzyme per daily serving—equivalent to approximately 2 packs of commercial natto—with vitamin K2 removed for broader compatibility.
Simple Daily Routine
Take just 2 soft capsules daily with water. The odor-free formula makes it easy to maintain consistent supplementation.
Quality Assured
Manufactured by Kobayashi Pharmaceutical, a trusted Japanese pharmaceutical company. JNKA-certified nattokinase meets strict quality standards.
Japanese Heritage
Combines traditional Japanese wisdom of natto and fish nutrition. Japan's sakana-natto approach supports cardiovascular wellness through time-tested ingredients.
Best For
Adults seeking to support healthy blood circulation, those who dislike natto's taste or smell, and people wanting convenient cardiovascular support.
Market Leader
Japan's No.1 nattokinase supplement brand by sales. The Nattokinase Series has earned widespread trust among Japanese consumers.
Is This Right For You?
Recommended For
Nattokinase EX is designed for those seeking natural nattokinase supplement support for healthy blood circulation and cardiovascular wellness.
If you want to maintain healthy blood circulation and cardiovascular function as you age
If you have limited natto consumption due to its distinctive taste or odor that you find unappealing
If you're seeking to support normal blood pressure within healthy ranges naturally
If you have insufficient fish intake and are looking for convenient EPA and DHA supplementation
If you're concerned about age-related changes in vascular health and blood vessel flexibility
If you maintain an active lifestyle and prioritize long-term cardiovascular wellness support
If you're looking for comprehensive circulatory support with multiple synergistic ingredients in one supplement
If you want the benefits of natto's cardiovascular-supporting nutrients in a convenient, odor-free capsule form
Why It Works
Benefits
Nattokinase EX delivers comprehensive cardiovascular support through seven carefully selected ingredients working together.
Supports Healthy Blood Circulation
Nattokinase is a fibrinolytic enzyme derived from natto that supports the body's natural processes for maintaining healthy blood flow. The 2500FU per serving works with your body's tissue plasminogen activator (t-PA) to support smooth circulation throughout the vascular system.
JNKA-certified enzymePromotes Cardiovascular Wellness
The combination of EPA (13mg) and DHA (72mg) from refined fish oil supports healthy blood lipid profiles and overall vascular function. These omega-3 fatty acids complement nattokinase's circulatory benefits for comprehensive cardiovascular support.
Research-backed ingredientsHelps Maintain Healthy Blood Pressure
Sardine peptides containing valytyrosine work by supporting healthy ACE enzyme activity, helping maintain blood pressure within normal ranges. Combined with tochu leaf extract's geniposidic acid, this formula supports vascular flexibility.
Functional ingredientsConvenient Natto-Free Solution
Unlike eating natto directly, this supplement provides nattokinase without odor or taste, with vitamin K2 removed during manufacturing. This makes daily supplementation simple and suitable for those who dislike natto or take certain medications.
Vitamin K2 removedThe Science
How It Works
Understanding how Nattokinase EX supports your cardiovascular system through multiple pathways.
Nattokinase + Fish: Two Traditional Components
Key benefits:
- Extracts nattokinase from natto's sticky fermented portion
- Adds EPA and DHA from fish oil
- Provides cardiovascular benefits of both traditional foods
Nattokinase Fibrinolytic Support
Unlike fresh natto:
- Consistent enzyme activity
- Vitamin K2 removed
- Works with your body's tissue plasminogen activator (t-PA)
Seven Synergistic Ingredients
- EPA and DHA from refined fish oil supporting healthy lipid profiles
- Sardine peptides (iwashi peptide) with valytyrosine for blood pressure support
- Tochu leaf extract with geniposidic acid for vascular flexibility
- Sara-sara red onion containing quercetin
The Science
Research & Evidence
What science and consumer validation tell us about nattokinase supplement benefits.
Complete Ingredient Profile—Nattokinase EX contains clearly disclosed amounts per daily serving including 2500FU nattokinase activity, DHA 72.3mg, EPA 13.7mg, and sardine peptide 500mg.
Japan's No.1 Nattokinase Brand—Kobayashi Pharmaceutical's Nattokinase Series holds the top position in Japan's nattokinase supplement market by sales.
A Note on Evidence: We present research on ingredients, not specific product claims. Individual results may vary. This supplement is not intended to diagnose, treat, cure, or prevent any disease.
Ingredient Research Highlights
NATTOKINASE
Nattokinase is a fibrinolytic enzyme discovered in natto (fermented soybeans). Research suggests it may support healthy blood flow by working with the body's natural fibrinolytic processes. The Japan Nattokinase Association recommends 2000FU or more per day.
Japan Nattokinase Association guidelinesEPA & DHA
EPA and DHA are omega-3 fatty acids found in fish oil. Research indicates they support healthy blood lipid profiles and cardiovascular function. These are essential fatty acids that the body cannot produce on its own.
Omega-3 fatty acid researchSARDINE PEPTIDES
Sardine peptides contain valytyrosine, which has been studied for its potential to support healthy blood pressure by influencing ACE enzyme activity. These peptides are derived from sardines through enzymatic processing.
Japanese functional food researchOur Curation Process
Why We Selected This Product
Every product at Naturacare undergoes rigorous evaluation before joining our collection.
信頼性
Reliability
Manufactured by Kobayashi Pharmaceutical, an established Japanese pharmaceutical company with rigorous quality standards. JNKA certification provides independent verification of nattokinase quality and activity.
革新性
Innovation
The vitamin K2 removal technology allows broader use of nattokinase benefits. The sakana-natto formulation combining natto and fish nutrients represents thoughtful product development.
実用性
Practicality
Just 2 capsules daily provide 2500FU nattokinase plus EPA, DHA, and supporting ingredients - equivalent to eating 2 packs of natto daily without the taste, odor, or preparation required.
Our Promise: We don't just import popular Japanese supplements - we investigate each product's formulation, manufacturing standards, and real-world reputation in Japan.
Nattokinase EX earned its place in our collection because it represents authentic Japanese cardiovascular wellness wisdom in a convenient, well-formulated supplement backed by a trusted pharmaceutical company.
Why Japan
The Japanese Advantage
Japan's supplement industry operates under some of the world's strictest quality standards. Combined with a cultural dedication to craftsmanship and centuries of wellness traditions, Japanese supplements represent a level of quality that's difficult to find elsewhere.
Rigorous Quality Standards
Japanese regulations require comprehensive testing at every stage of production, with standards that often exceed international requirements.
GMP-Certified Manufacturing
All our products come from facilities that meet Japan's strict GMP (Good Manufacturing Practice) certification requirements.
Centuries of Tradition
Many Japanese supplements draw on ingredients and formulations refined over generations, combining ancient wisdom with modern science.
Transparent Sourcing
Japanese manufacturers maintain complete traceability, so you know exactly where every ingredient comes from.
Directions
How to Use
Simple daily routine for optimal cardiovascular support.
Consume with water or warm liquid, preferably with meals to support absorption.
Swallow capsules whole without chewing to preserve active enzyme integrity.
Tips for Best Results
- Take at the same time daily to build a consistent routine
- Consume with meals for better absorption
- Store in a cool, dry place away from direct sunlight and high humidity
- Allow 4-12 weeks of consistent use for optimal cardiovascular benefits
- Maintain a balanced diet with varied foods
- Do not exceed the recommended daily dosage of 2 capsules
What's Inside
Ingredients
Seven cardiovascular-supporting ingredients in one comprehensive formula.
Nattokinase
Fibrinolytic enzyme from natto bacteria culture extract (32.2mg)
DHA
Omega-3 fatty acid from refined fish oil
Sardine Peptides
Iwashi peptide containing valytyrosine for blood pressure support
Ingredients: (Content per daily recommended intake at time of manufacture): Nattokinase-containing Bacillus natto culture extract (37.1 mg), EPA-containing refined fish oil (18.8 mg), DHA-containing refined fish oil (166.9 mg), Sardine peptide (50.0 mg), Eucommia leaf extract (50.0 mg), Sarasara Red® (Onion) (25.0 mg), Vitamin E-containing vegetable oil (0.9 mg), Soybean oil (129.3 mg), Indigestible dextrin (38.0 mg), Beeswax (39.0 mg), Glycerin fatty acid ester (39.0 mg), Soy lecithin (6.0 mg), and capsule encapsulation materials consisting of Gelatin, Glycerin, and Phytic acid. --- Gelatin, DHA-containing refined fish oil, Soybean oil, Sardine peptide (Iwashipeptide), Eucommia leaf extract, Indigestible dextrin, Nattokinase-containing Bacillus natto culture extract, Onion, EPA-containing refined fish oil, Glycerin, Beeswax, Glycerin fatty acid ester, Lecithin (derived from soybeans), Phytic acid, Vitamin E.
Allergen Information: Contains: Soybeans, Gelatin, Fish (sardine, tuna, iwashi). Free from: Wheat, Eggs, Milk, Peanuts, Tree nuts, Crustaceans, Shellfish. Note: Vitamin K2 has been removed during manufacturing.
Important Information
Safety & Precautions
Please read before use.
Allergies
Not recommended for individuals allergic to soybeans, gelatin, or fish products. Check full ingredient list if you have any food allergies.
Pregnancy & Nursing
Pregnant, nursing, or planning pregnancy women should consult physician before use.
Medications
Consult your healthcare provider if taking anticoagulant medications (blood thinners) or antiplatelet drugs. While vitamin K2 has been removed, nattokinase may interact with blood-thinning medications. Those scheduled for surgery should consult their doctor beforehand.
Dosage
Do not exceed recommended daily dosage of 2 capsules. Do not consume in large quantities over short periods.
Discontinue Use
Discontinue use if any adverse reactions occur including rash, stomach discomfort, or allergic symptoms.
Disclaimer
This is a dietary supplement, not a medicine. It supports wellness but does not treat, cure, or prevent any disease. Individuals with bleeding disorders or clotting abnormalities should seek medical advice before use.
Storage
Store away from direct sunlight and high humidity to maintain product quality. Keep out of reach of infants and young children.
Details
Product Specifications
Questions
Frequently Asked Questions
Nattokinase supports the body's natural processes for maintaining healthy blood circulation. This supplement delivers 2500FU of purified nattokinase with vitamin K2 removed for broader compatibility.
While vitamin K2 is removed from this formula, nattokinase may enhance anticoagulant effects. Individuals with bleeding disorders, those scheduled for surgery, and pregnant or nursing women should also seek medical advice first.
Natural natto contains both, but this nattokinase supplement has vitamin K2 removed during manufacturing, making it suitable for those who need to avoid vitamin K.
Plus, this supplement includes synergistic EPA, DHA, sardine peptides, and tochu extract not available in plain natto. The vitamin K2 has also been removed, and enzyme activity is consistent—unlike fresh natto which can vary.
This concentration equals approximately 2 packs (100g) of commercial natto, providing a clinically-studied dosage for cardiovascular support.
However, optimal cardiovascular benefits typically manifest with consistent daily use over 4-12 weeks as ingredients work cumulatively.
Many users maintain regular supplementation as part of ongoing cardiovascular health maintenance routines. Always follow recommended dosage and consult healthcare provider if concerned.
The purified, encapsulated nattokinase remains stable at room temperature throughout the product's shelf life.