Japanese Weight Loss Supplements: Evidence-Based Guide

You've probably seen them while scrolling through Amazon or browsing specialty import sites — capsules, tablets, and powders from Japanese brands you've never heard of, all promising to help with weight management. Maybe you've encountered products like Naishitoru, Onaka, or mysterious "night diet enzymes" and wondered if any of them actually work — or if they're just clever marketing from a country known for its slim population.

Here's what makes Japanese weight loss supplements genuinely different from what you'll find in most markets: many of them are backed by government-reviewed clinical evidence. Japan operates a unique regulatory system called FOSHU that requires human clinical trials before a product can make health claims — a standard far stricter than what most countries require for dietary supplements. The result is a class of products that sit somewhere between typical supplements and pharmaceuticals in terms of evidence rigor.

Our team reviewed over 25 clinical studies, systematic reviews, and meta-analyses — spanning both English and Japanese-language research — to create this guide. We'll walk you through every major category of Japanese weight loss supplements, explain the science behind each one, and help you separate evidence-backed options from marketing hype.

Why Japanese Weight Loss Supplements Are Different

Japan has one of the lowest obesity rates among developed nations, yet its supplement industry is one of the most scientifically rigorous in the world. This isn't a coincidence — it reflects a fundamentally different approach to weight management that starts with how the country regulates health products.

The Japanese Regulatory Advantage

Japan operates a three-tier system for health-related food products, each with escalating evidence requirements:

Foods for Specified Health Uses (FOSHU / 特定保健用食品) sit at the top. Each product must undergo individual review by Japan's Consumer Affairs Agency (消費者庁), with mandatory human clinical trials on the final formulation — not just the individual ingredients. Products that pass receive an official FOSHU seal. The body fat and neutral fat category alone represents approximately 31.5% of the total FOSHU market, valued at roughly ¥193 billion ^[17].

Foods with Function Claims (機能性表示食品 / FFC), launched in 2015, require companies to submit either human clinical trials or systematic reviews to the Consumer Affairs Agency before making health claims. All evidence filings are publicly searchable, giving consumers unprecedented transparency. Hundreds of body fat-related products are registered under this system ^[18].

Ordinary supplements occupy the third tier, with no mandatory pre-market evidence review — similar to the supplement framework in most other countries.

This regulatory structure means that when you see a FOSHU seal or FFC registration on a Japanese weight loss product, there's a documented evidence trail behind the claim. That's a consumer trust signal that simply doesn't exist in most supplement markets.

Japan's Preventive Health Culture

Japan also approaches obesity itself differently. The country defines obesity at BMI ≥25 (compared to BMI ≥30 in most international guidelines), and mandates annual metabolic syndrome screenings for all citizens aged 40-74 through the Metabo Health Checkup System (特定健康診査) ^[19]. This prevention-first philosophy drives strong consumer demand for evidence-based weight management supplements — and incentivizes manufacturers to invest in clinical research.

Understanding FOSHU and FFC: Japan's Evidence-Based Certification Systems

Understanding Japan's two main certification systems is key to navigating Japanese weight loss supplements with confidence. Both require evidence — they differ in review process, not in demanding science.

FOSHU (Foods for Specified Health Uses / 特定保健用食品)

Unlike most countries where supplement companies can make vague health claims with minimal oversight, FOSHU requires each individual product to be reviewed and approved by the government — with human clinical trial data on the actual product, not just its ingredients. This is closer to how pharmaceuticals are regulated than how supplements typically work.

What FOSHU approval means for consumers:

• The health claim has been verified through clinical trials
• The recommended dosage is based on evidence from those trials
• The product carries an official government seal for easy identification
• Ongoing safety monitoring is required

FFC (Foods with Function Claims / 機能性表示食品)

Launched in 2015, FFC is the certification most commonly found on Japanese supplements available internationally. Companies must submit either human clinical trial data or systematic reviews to Japan's Consumer Affairs Agency before making any health claims. The key difference from FOSHU is that the government does not individually review each product — but all evidence filings are publicly searchable in a national database, giving consumers and researchers direct access to verify claims.

What FFC registration means for consumers:

• The company has filed clinical evidence supporting its health claims
• That evidence is publicly available and verifiable
• The product meets safety assessment requirements
• The filing was made under corporate responsibility — submitting false data carries legal consequences

Many of the products in this guide carry FFC registration, while ingredients like green tea catechins and resistant dextrin also appear in FOSHU-certified products. When evaluating Japanese supplements, either certification is a meaningful evidence signal compared to unregulated supplement markets.

Japanese Weight Loss Supplement Categories at a Glance

Before diving into each category, here's an overview of how Japanese weight loss supplements differ by mechanism:

Understanding which mechanism matches your goals is the first step to choosing the right supplement. Each category targets a different aspect of weight management, and the evidence base varies considerably.

Fat Burning Supplements

Fat burning supplements are the most popular category of Japanese weight loss products. They work by increasing the body's ability to oxidize stored fat, often through activation of brown adipose tissue — the metabolically active fat that generates heat by burning calories.

Kudzu Flower Isoflavones (Pueraria Flower Extract): Moderate Evidence

Kudzu flower extract (PFE) is one of Japan's most distinctive weight loss ingredients, used in several FFC-registered products. Unlike soy isoflavones, the isoflavone profile in kudzu flowers — including tectoridin as the key active compound — has a different molecular structure with no observed estrogenic effects at recommended doses ^[7].

The clinical evidence comes from a well-designed placebo-controlled randomized trial that tested PFE at 300 mg/day. Participants showed significant reductions in visceral fat area as measured by CT scan — a more precise measurement than body weight alone. The proposed mechanism involves increased energy expenditure through upregulated brown adipose tissue UCP1 expression ^[6]. A re-analysis of the trial data focused specifically on non-obese subjects confirmed the visceral fat reduction effect ^[8].

You may have encountered kudzu flower isoflavones in products like Onaka by Pillbox, one of the most popular FFC-registered fat burning supplements in Japan. For a detailed look at this specific product and the research behind it, see our Onaka fat burner review.

Black Ginger (Kaempferia parviflora) Polymethoxyflavone: Moderate Evidence

Black ginger, originally from Thailand but extensively researched and commercialized in Japan, contains polymethoxyflavones (PMFs) that target fat metabolism through a distinctive pathway. A randomized, double-blind, placebo-controlled trial in Japanese overweight individuals found that PMFs significantly reduced visceral fat by activating brown adipose tissue and promoting fat oxidation ^[9].

Preclinical studies support this mechanism, showing that black ginger extract reduces body fat mass and adipocyte size while increasing energy expenditure ^[10]. Intriguingly, research also suggests black ginger may enhance circadian rhythm function, which could support metabolic health through improved sleep-wake cycle regulation ^[11].

FANCL, one of Japan's leading pharmaceutical and supplement companies, uses black ginger PMF as the key functional ingredient in their Black Ginger Supplement, which is registered under Japan's Foods with Function Claims system.

Bofutsushosan (防風通聖散) — Kampo Medicine: Moderate-Strong Evidence

Bofutsushosan (BTS) is not a supplement — it's a traditional Kampo herbal formula classified as an OTC pharmaceutical in Japan, meaning it undergoes pharmaceutical-grade manufacturing and quality control. Containing 18 crude herbal compounds, it has been used in traditional medicine for centuries and is now backed by modern clinical evidence.

A systematic review and meta-analysis of randomized controlled trials found that BTS significantly improves BMI in participants with obesity ^[12]. An earlier trial of 127 obese patients also demonstrated significant weight reduction, particularly in patients matching specific Kampo diagnostic patterns ^[13]. The mechanisms involve reduced white adipose tissue weight and decreased inflammation markers ^[14].

You may recognize BTS by its commercial name: Naishitoru (ナイシトール) by Kobayashi Pharmaceutical — Japan's bestselling OTC anti-obesity product. An important note: BTS contains Ephedrae herba (麻黄, ephedra), a natural stimulant that raises significant safety considerations covered in our Safety section below.

Calorie and Carb Blockers

These supplements work by reducing the absorption of dietary fats and carbohydrates, effectively lowering the caloric impact of meals.

Resistant Dextrin (難消化性デキストリン): Strong Evidence

Resistant dextrin (indigestible dextrin) is arguably the most widely used FOSHU ingredient in Japan for body fat and blood sugar management. This water-soluble fiber reduces the absorption of fat and sugar from meals when taken alongside food.

A systematic review with meta-analysis of randomized controlled trials confirmed that resistant dextrin produces significant weight loss in overweight adults ^[16]. Notably, the research found that initial weight loss response at 12 weeks predicted overall outcome — suggesting that patience matters with this ingredient, and early non-responders may benefit from a different approach.

Resistant dextrin holds both FOSHU approval in Japan and GRAS (Generally Recognized as Safe) status in the US, making it one of the most thoroughly vetted weight management ingredients available. You'll find it in top-selling Japanese products like Otsuka's Kenja no Shokutaku (賢者の食卓) and Ito-en's Tokucha.

Gymnema, Chitosan, and Other Absorption Blockers: Moderate Evidence

Japanese carb-blocking supplements often combine multiple absorption-blocking ingredients. Gymnema sylvestre reduces sugar absorption in the intestine, while chitosan (derived from crustacean shells) binds to dietary fats before they can be absorbed. FANCL's Calorie Limit product uses this multi-ingredient approach.

The evidence for these individual ingredients is moderate globally, though the combination approach used in Japanese formulations lacks large-scale independent trials. Chitosan carries an important caveat: it may reduce absorption of fat-soluble vitamins (A, D, E, K) and certain medications, so timing matters.

Enzyme and Metabolism Boosters

Japanese enzyme supplements represent a unique product category rarely seen outside Japan. These products contain fermented plant extracts — sometimes hundreds of different fruits, vegetables, and herbs — that undergo extended fermentation periods to produce concentrated enzyme blends.

The concept behind products like the Night Diet Enzyme line is that supporting metabolic enzyme activity during rest can enhance overnight metabolism. While this is a culturally significant and popular product category in Japan, the clinical trial evidence is limited compared to categories like green tea catechins or resistant dextrin.

Evidence assessment: Emerging. The fermentation process and the sheer variety of plant-derived enzymes are well-documented from a manufacturing perspective, but large-scale clinical trials specifically measuring weight loss outcomes are lacking. If you're drawn to this category, realistic expectations are important — consider it a metabolic support supplement rather than a primary weight loss tool.

Green Tea Catechin Supplements

Green tea catechins — particularly epigallocatechin gallate (EGCG) — are the most extensively studied Japanese weight loss ingredient, with multiple meta-analyses providing Level 1 evidence.

The Evidence: Strong

A landmark meta-analysis of 15 randomized controlled trials (1,243 participants) found that green tea catechins with caffeine significantly reduced BMI by 0.55 kg/m² and body weight by 1.38 kg compared to caffeine alone. An important finding: EGCG alone (without caffeine) showed no significant effect, suggesting the catechin-caffeine synergy is critical for weight loss benefits ^[1].

Additional meta-analyses have confirmed these findings. A dose-response analysis found significant body weight reductions in obese and overweight subjects, with benefits plateauing at higher doses ^[2]. A GRADE-assessed review found significant effects on body fat percentage reduction ^[3]. And when combined with exercise training, green tea catechins enhance weight loss effects beyond what exercise alone achieves ^[4].

A 12-week randomized, double-blind, placebo-controlled trial specifically studied green tea beverages enriched with catechins containing a galloyl moiety (CGM) and found they reduced body fat in moderately obese adults ^[5].

Beyond weight management, green tea catechins also significantly reduce blood lipids ^[20] and blood pressure ^[21], providing broader cardiovascular benefits.

Important context: While the evidence is strong, the magnitude of weight loss is modest — typically 1-2 kg over placebo in most studies. Green tea catechins are most effective as a complement to diet and exercise, not a replacement. For a deeper dive into green tea for weight management, see our complete guide to fat-burning teas and our guide to green tea extract for weight loss.

Japanese Tea Companies Lead the Category

Japan's largest tea companies produce FOSHU-certified catechin products with standardized catechin content. Ito-en, the company behind Japan's best-selling bottled green tea, offers catechin supplements with controlled, consistent dosing — a significant advantage over simply drinking green tea, where catechin content varies widely depending on brewing method and tea grade.

Functional Teas Beyond Catechins

While catechins dominate green tea research globally, Japan's functional food innovation has produced a newer category of teas that work through entirely different biological mechanisms. These products are registered under the FFC system, with evidence reviewed by the Consumer Affairs Agency — and their active ingredients are virtually unknown outside Japan.

HMPA (Dihydroferulic Acid): Emerging Evidence

HMPA — formally 3-(4-hydroxy-3-methoxyphenyl)propionic acid — is a polyphenol metabolite naturally found in fermented rice bran and traditional Japanese black vinegar (kurozu). Unlike catechins, which increase thermogenesis through the COMT pathway, HMPA works by activating the GPR41 receptor, which triggers a PPARalpha-mediated signaling cascade that promotes hepatic lipid catabolism — essentially stimulating the liver to break down stored fat ^[24]. Preclinical research confirms that HMPA supplementation suppresses hepatic triglyceride accumulation and body weight gain in high-fat diet models, with effects dependent on both GPR41 and gut microbiota ^[25].

HMPA has become the second most popular functional ingredient in Japan's FFC system (behind GABA), with over 61 approved products as of recent data. FFC-approved claims include reduction of visceral fat and waist circumference in individuals with BMI 23-30, at a functional dose of 23mg per day. The evidence supporting these claims has been filed with Japan's Consumer Affairs Agency, though English-language human clinical trial publications remain limited — most mechanistic studies to date are preclinical.

Evidence assessment: Emerging (FFC-reviewed). The GPR41 mechanism is well-characterized in published research, and the volume of FFC registrations indicates regulatory acceptance. However, independent human clinical trials published in peer-reviewed journals are still building. This ingredient category is early in its evidence lifecycle compared to catechins or resistant dextrin.

Plant-Based Postbiotics for Gut Regularity: K-1 Lactic Acid Bacteria

Some Japanese functional teas pair metabolic ingredients like HMPA with K-1 lactic acid bacteria (Lactobacillus casei subsp. casei 327) — a heat-killed postbiotic originally isolated from brown rice bran by Kameda Seika, a Japanese company with over 25 years of rice-based lactic acid bacteria research.

K-1 promotes colonic serotonin synthesis, which stimulates intestinal peristalsis and improves bowel regularity ^[28]. A randomized, double-blind, placebo-controlled trial with 104 participants found that K-1 significantly increased bowel movement frequency (+1.3 times/week vs +0.7 for placebo, p=0.025) and fecal volume ^[27]. K-1 holds 38+ FFC product registrations and ranks as the top heat-killed lactic acid bacterium in Japan's FFC system.

An important distinction: K-1 targets bowel regularity, not fat reduction directly. In functional tea formulations, it complements HMPA's metabolic mechanism — addressing digestive wellness alongside fat metabolism. This dual-mechanism approach reflects Japan's emphasis on holistic wellness rather than single-pathway solutions.

Products like Teaflex, Japan's first FFC-registered green tea combining both HMPA and K-1, represent this newer functional tea category.

Safety Considerations

Weight loss supplements carry specific safety considerations that vary by category. This section is essential reading before trying any product.

Identifying Legitimate Japanese Products

The FDA has issued public safety notifications about fraudulent products sold under names like "Japan Rapid Weight Loss Diet Pills." These counterfeit products contained undeclared pharmaceutical drugs:

• "Japan Rapid Weight Loss Diet Pills Green" contained phenolphthalein — a suspected carcinogen and genotoxic agent that was withdrawn from medical use ^[22]
• "Japan Rapid Weight Loss Diet Pills Yellow" contained both sibutramine (a cardiovascular risk drug withdrawn from the market) and phenolphthalein ^[23]

How to verify authenticity: Purchase from authorized retailers, look for the FOSHU seal or FFC registration number, and verify the manufacturer is a recognized Japanese company (FANCL, Kobayashi, Ito-en, DHC, Pillbox, etc.). Avoid products with vague branding, dramatic weight loss claims, or no traceable manufacturer.

Side Effects by Category

Drug Interactions

• Catechin/EGCG: May interact with anticoagulants (warfarin), beta-blockers, and some chemotherapy drugs. Caffeine content can amplify effects of other stimulants.
• Bofutsushosan: Significant interaction risk due to ephedra — contraindicated with MAOIs, cardiac glycosides, and stimulant medications. The licorice component may interact with antihypertensives and diuretics.
• Chitosan: May reduce absorption of fat-soluble medications — separate intake timing by at least 2 hours.
• Blood sugar supplements (salacia, resistant dextrin): May enhance effects of diabetes medications — blood sugar monitoring is recommended if combining.

Who Should Avoid

• Bofutsushosan: Anyone with heart disease, high blood pressure, thyroid disorders, or urinary difficulties. The ephedra content makes this the highest-risk category among Japanese weight loss products.
• High-dose EGCG supplements: Those with pre-existing liver conditions or taking hepatotoxic medications.
• All categories: Pregnant and nursing women should avoid weight loss supplements due to insufficient safety data. Always consult your healthcare provider before starting any supplement regimen, especially if you take medications.

Realistic Expectations

Clinical trials consistently show weight loss in the range of 1-3 kg over placebo across most supplement categories — meaningful, but modest. Results typically appear after 8-12 weeks of consistent use. Japanese weight loss supplements work best as adjuncts to a balanced diet and regular exercise, never as replacements. No supplement can overcome a sustained caloric surplus.

What Most Weight Loss Guides Miss About Japanese Supplements

Japan Measures What Other Markets Don't

Most international weight loss studies use body weight or BMI as their primary outcome. Japanese clinical trials, particularly those for FOSHU applications, frequently use CT-measured visceral fat area — a far more precise and clinically relevant measurement. Visceral fat is the metabolically dangerous fat that surrounds internal organs and drives metabolic syndrome risk. This focus on visceral fat over simple body weight reflects Japan's emphasis on metabolic health, not just aesthetics.

Why this matters: When Japanese studies report "reduced abdominal fat," they often mean it was measured by CT scan — a level of precision that most supplement studies globally don't achieve. This makes the evidence from Japanese trials particularly valuable for understanding where fat loss actually occurs.

A Regulatory Framework Without Equivalent

The FOSHU system requires something that no major supplement market replicates: government review of clinical trial data on the final product before health claims are permitted. In most countries, supplement companies can make structure/function claims with minimal evidence and no pre-market review. Japan's approach creates a documented evidence trail for each approved product.

Why this matters: When you see a FOSHU seal on a Japanese weight loss supplement, the claim "reduces body fat" has been verified through clinical trials reviewed by a government agency. This isn't a guarantee of dramatic results, but it's a consumer protection mechanism that most supplement markets lack.

Ingredients You Won't Find in International Markets

Several of the most evidence-backed Japanese weight loss ingredients are virtually unknown outside Japan. Kudzu flower isoflavones (not to be confused with kudzu root, which is more widely known) have a unique molecular profile and clinical data specifically for visceral fat reduction ^[6]. Black ginger polymethoxyflavone activates brown adipose tissue through a mechanism distinct from capsaicin or caffeine ^[9]. Bofutsushosan, a pharmaceutical-grade Kampo formula, combines 18 herbal compounds in a formulation refined over centuries and validated by modern meta-analysis ^[12].

Why this matters: If you're only reading English-language content about weight loss supplements, you're missing an entire class of ingredients with clinical evidence that simply hasn't been translated into international awareness yet.

Japan Intervenes Earlier — and This Shapes Their Supplements

Japan defines obesity at BMI ≥25 (compared to BMI ≥30 in most international guidelines) and requires metabolic syndrome screenings for all adults over 40 ^[19]. This lower threshold means Japanese supplements are often designed for prevention and early intervention rather than treatment of established obesity. The concept of mibyou (未病) — addressing health concerns in a pre-disease state — permeates Japan's approach to weight management.

Why this matters: Japanese weight loss supplements tend to target gradual, sustained metabolic improvement rather than dramatic short-term weight loss. If you're looking for slow, steady support alongside lifestyle changes, this design philosophy aligns well with sustainable weight management goals.

Our Recommendations

Based on our review of the clinical evidence, we've selected products across the major categories of Japanese weight loss supplements. Each recommendation is verified in the Naturacare catalog and chosen for its evidence base, manufacturer credibility, and formulation quality.

For Fat Burning: Onaka (FFC-registered)

Why We Selected This: Onaka is registered under Japan's Foods with Function Claims system, backed by clinical trial data showing visceral fat reduction through kudzu flower isoflavones. From Pillbox Japan, it uses 300 mg of Pueraria flower extract containing tectoridin — the same dosage and ingredient studied in the published clinical trials. We chose it because the evidence specifically demonstrates visceral fat reduction measured by CT scan, not just body weight changes.

View Onaka →

For Metabolic Activation: FANCL Black Ginger Supplement (FFC-registered)

Why We Selected This: FANCL's Black Ginger supplement uses polymethoxyflavones (PMF) from Kaempferia parviflora, registered under Japan's Foods with Function Claims system. A randomized, double-blind, placebo-controlled trial found that PMFs significantly reduced visceral fat by activating brown adipose tissue — a mechanism distinct from other fat-burning ingredients in this guide. FANCL brings over four decades of pharmaceutical and supplement expertise to this formulation.

View FANCL Black Ginger Supplement →

For Calorie Management: FANCL Calorie Limit

Why We Selected This: From FANCL, a company with over four decades in pharmaceutical and supplement research, Calorie Limit uses a multi-ingredient approach to reduce absorption of dietary fats and carbohydrates. FANCL is one of Japan's most trusted supplement brands with an extensive research portfolio, and their Calorie Limit line is among the best-selling carb-blocking supplements in Japan.

View FANCL Calorie Limit →

For Enzyme Support: Night Diet Enzyme GOLD+

Why We Selected This: Night Diet Enzyme GOLD+ represents a supplement category that's uniquely Japanese — fermented enzyme blends designed to support metabolism. With 680 living enzymes derived from fermented plant extracts, this product reflects Japan's deep tradition of fermented foods applied to supplement science. While clinical trial evidence for enzyme supplements is still emerging, the fermentation technology and ingredient diversity are well-documented.

View Night Diet Enzyme GOLD+ →

For Green Tea Benefits: Catechin Supplements by Ito-en (FFC-registered)

Why We Selected This: Ito-en is Japan's largest tea company, and their catechin supplements offer standardized catechin content — ensuring consistent dosing that the clinical research supports. Green tea catechins have the strongest evidence base of any Japanese weight loss ingredient, with multiple meta-analyses confirming benefits for body weight and body fat reduction. This product is registered with Japan's Consumer Affairs Agency (FFC registration F350).

View Catechin Supplements →

For Functional Tea: Teaflex Slim Cleanse Green Tea (FFC-registered)

Why We Selected This: Teaflex is Japan's first FFC-registered green tea combining HMPA — a polyphenol metabolite that targets hepatic fat metabolism through the GPR41 receptor — with 50 billion K-1 postbiotic bacteria for digestive regularity. At 23mg of HMPA per serving, it delivers the standard functional dose used across FFC filings. This product represents a newer category of Japanese functional teas that work through mechanisms entirely different from traditional catechin-based products.

View Teaflex →

Product Comparison

Browse our full Fat Burning & Slimming collection for more options across all categories.

Conclusion

Japanese weight loss supplements represent a unique intersection of traditional knowledge and modern clinical science, backed by a regulatory framework that demands evidence in ways most supplement markets don't. From FOSHU-certified fat burners with CT-measured clinical trial results to traditional Kampo formulas validated by systematic reviews, the category offers genuine options for people seeking evidence-based metabolic support.

The key takeaways from our review: green tea catechins have the strongest and deepest evidence base; kudzu flower isoflavones and black ginger offer Japanese-unique approaches to visceral fat with solid clinical trial support; and bofutsushosan provides the most potent option but carries the most safety considerations. Across all categories, realistic expectations matter — these supplements produce modest, gradual improvements that complement a healthy lifestyle.

Whatever category interests you, verify the product comes from a recognized Japanese manufacturer, look for FOSHU certification or FFC registration when available, and consult your healthcare provider if you take medications. Evidence-based weight management is a long game, and Japanese supplement science is designed for exactly that approach.

Sources & Further Reading

1. Effect of green tea catechins with or without caffeine on anthropometric measures: a systematic review and meta-analysis — American Journal of Clinical Nutrition
2. The effect of green tea supplementation on obesity: A systematic review and dose-response meta-analysis of RCTs — Phytotherapy Research
3. Effects of green tea extract supplementation on body composition, obesity-related hormones and oxidative stress markers: a GRADE-assessed systematic review and dose-response meta-analysis of RCTs — British Journal of Nutrition
4. Does green tea catechin enhance weight-loss effect of exercise training in overweight and obese individuals? A systematic review and meta-analysis — Journal of the International Society of Sports Nutrition
5. Green tea beverages enriched with catechins with a galloyl moiety reduce body fat in moderately obese adults: A randomized double-blind placebo-controlled trial — Food & Function
6. Consumption of Pueraria Flower Extract Reduces Body Mass Index via a decrease in the visceral fat area — PMC
7. Safety and Efficacy Assessment of Isoflavones from Pueraria (Kudzu) Flower Extract in Ovariectomised Mice — International Journal of Molecular Sciences
8. Re-statistical analysis of kudzu flower extract on visceral fat in non-obese subjects — Pharmacometrics
9. Polymethoxyflavone purified from Kaempferia parviflora reduces visceral fat in Japanese overweight individuals: a randomized, double-blind, placebo-controlled study — Food & Function
10. Kaempferia parviflora rhizome extract exerts anti-obesity effect in high-fat diet-induced obese mice — Food & Nutrition Research
11. Black ginger extract enhances circadian rhythm and promotes lipolysis in mice fed a high-fat diet — Journal of Functional Foods
12. Japanese traditional Kampo medicine bofutsushosan improves body mass index in participants with obesity: A systematic review and meta-analysis — PLoS ONE
13. The effect of Bofutsushosan on weight reduction in humans — Journal of Kampo Medicine
14. Mechanisms for the anti-obesity actions of bofutsushosan in high-fat diet-fed obese mice — Chinese Medicine
15. Bofutsushosan attenuates white adipose tissue weight gain — Journal of Clinical Biochemistry and Nutrition
16. Effects of resistant dextrin for weight loss in overweight adults: a systematic review with a meta-analysis of randomized controlled trials — Journal of Pharmaceutical Health Care and Sciences
17. 保健機能食品の課題と展望 (Health Functional Foods: Issues and Prospects) — Journal of Japanese Society of Nutrition and Food Science
18. 日本における機能性表示食品の現状分析と課題 (Current Analysis and Issues of FFC in Japan) — Vitamins
19. MHLW Metabo Health Checkup System — Ministry of Health, Labour and Welfare
20. Effect of green tea consumption on blood lipids: a systematic review and meta-analysis of randomized controlled trials — Nutrition Journal
21. Green tea catechins and blood pressure: a systematic review and meta-analysis of randomised controlled trials — European Journal of Nutrition
22. FDA Public Notification: "Japan Rapid Weight Loss Diet Pills Green" — FDA
23. FDA Public Notification: "Japan Rapid Weight Loss Diet Pills Yellow" — FDA
24. HMPA contributes to improved hepatic lipid metabolism via the GPR41 signaling pathway — Scientific Reports
25. HMPA Produced from HMCA by Gut Microbiota Improves Host Metabolic Condition in Diet-Induced Obese Mice — Nutrients
26. A gut microbial metabolite of dietary polyphenols reverses obesity-driven hepatic steatosis — PNAS
27. Effects of heat-killed Lactobacillus casei subsp. casei 327 on defecation in healthy volunteers — Bioscience of Microbiota, Food and Health
28. Heat-killed Lactobacillus casei subsp. casei 327 promotes colonic serotonin synthesis in mice — Journal of Functional Foods

This article is for informational purposes only and does not constitute medical advice. Consult a healthcare professional before starting any new health regimen, especially if you have existing health conditions or take medications. Statements about dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease.