Key Takeaways
Active Ingredient + Dose
Contains 100 μg of clinically studied Tripeptide MKP and 12.3 mg of GABA per daily serving of three coated tablets.
Clinical Evidence
A 12-week randomized, double-blind, placebo-controlled trial showed MKP reduced systolic blood pressure by a mean of 7.6 mmHg versus placebo.
Certification
Registered as a Food with Functional Claims (機能性表示食品, notification number E493) under Japan's Consumer Affairs Agency — evidence-backed, not self-declared.
Ease of Use
Just three small coated tablets taken once daily with water — no specific meal timing required, no complicated schedule to follow.
Manufacturer Credibility
Made by FANCL Corporation, one of Japan's most respected no-additive supplement brands, with a manufacturing philosophy built on minimal, purposeful formulation.
Formula Cleanliness
Contains only two functional actives plus minimal excipients — consistent with FANCL's no-additive (無添加) philosophy, with no colorants or unnecessary preservatives.
Is This Right For You?
Recommended For
Designed for healthy adults with high-normal blood pressure — systolic readings between 130 and 139 mmHg and/or diastolic between 85 and 89 mmHg — who want evidence-based, daily non-pharmaceutical support.
If you have a systolic blood pressure between 130–139 mmHg or a diastolic reading of 85–89 mmHg, this product is formulated for your precise range.
If your diet is high in sodium — from processed foods, restaurant meals, or Japanese seasonings — this formula may help your body maintain cardiovascular balance.
If a busy schedule or physical limitations make regular aerobic exercise difficult, this daily tablet may help support vascular health in the absence of consistent activity.
If work-related stress or irregular hours are contributing to elevated readings, GABA's autonomic-balancing mechanism may offer meaningful support alongside daily routines.
If you want to proactively maintain healthy blood pressure as part of a long-term wellness strategy, this provides daily evidence-based support calibrated to your life stage.
If diet and exercise efforts have not fully brought your readings into a healthy range, this dual-ingredient formula may help close the remaining gap.
If regular alcohol consumption is part of your lifestyle and you are concerned about blood pressure, this formula may help support healthy levels alongside moderation efforts.
If high blood pressure runs in your family and you want evidence-backed preventive action before clinical thresholds are reached, this is a practical and accessible starting point.
Why It Works
Benefits
Tripeptide MKP inhibits ACE-driven vasoconstriction while GABA regulates autonomic nervous system tone — two complementary mechanisms supporting healthy blood pressure from within.
Clinically Supported Blood Pressure Management
Combines two ingredients targeting distinct mechanisms: Tripeptide MKP (100 μg/day) inhibits ACE to reduce vascular constriction, while GABA (12.3 mg/day) helps regulate autonomic nervous system balance. Together, they support blood pressure maintenance in adults with high-normal readings — backed by published clinical evidence and Japan's functional food certification.
Human clinical trial evidenceACE Inhibition for Vascular Relaxation
Tripeptide MKP — derived from casein (milk protein) — inhibits angiotensin-converting enzyme (ACE), which drives the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor. By reducing ACE activity, MKP helps relax blood vessels and supports lower pressure readings through a food-grade, clinically evaluated ingredient.
Peer-reviewed mechanistic researchMeasurable Results Supported Within 12 Weeks
In a published 12-week randomized trial, Tripeptide MKP significantly reduced systolic blood pressure by a mean of 7.6 mmHg versus 2.7 mmHg in the placebo group (p < 0.05). Reductions were observable from Week 4, providing an evidence-based timeline for users beginning daily supplementation.
Randomized controlled trialSimple Daily Routine, No Prescription Required
Three small coated tablets taken once daily, with no strict meal-timing requirement. Consistent with FANCL's no-additive philosophy, the formula contains only functional actives and minimal excipients. Certified under Japan's Food with Functional Claims framework (notification E493), making it accessible over the counter without a prescription.
Japan Functional Food certifiedThe Science
How It Works
Understanding how FANCL Blood Pressure Support's functional ingredients work for blood pressure reduction.
How Tripeptide MKP Inhibits ACE-Driven Vascular Constriction
Adults with High-Normal Blood Pressure
Dual Approach
The Science
Research & Evidence
FANCL Blood Pressure Support's functional ingredients are each backed by research studies.
Clinical Evidence: Daily GABA Intake Supports Healthy Blood—A placebo-controlled, double-blind clinical study involving 108 adults with mildly elevated blood pressure (systolic 130–139 mmHg or diastolic 85–89 mmHg) examined the effects of consuming 12.3mg of GABA daily for 12 weeks. Results showed that compared to the placebo group: - Systolic (upper) blood pressure showed measurable reduction after 8 weeks of intake - Diastolic (lower) blood pressure showed measurable reduction after 12 weeks of intake Both measures gradually returned toward baseline after discontinuation, suggesting that consistent daily intake is important for maintaining results. Source: Nippon Shokuhin Kagaku Kogaku Kaishi, 51(2), 79–86 (2004). This is a representative research review and not a clinical trial conducted using this specific product.
Clinical Evidence: Tripeptide MKP Helps Lower Elevated Systolic Blood Pressure—A placebo-controlled, double-blind clinical study of 102 adults with mildly to moderately elevated blood pressure examined the effects of taking 100μg of Tripeptide MKP daily for 12 weeks. Participants were divided into two groups: - Normal-high blood pressure (systolic 130–139 mmHg or diastolic 85–89 mmHg): 61 participants - Grade I hypertension (systolic 140–159 mmHg or diastolic 90–99 mmHg): 41 participants After 12 weeks, the MKP group showed a significantly greater reduction in systolic (upper) blood pressure compared to the placebo group (approximately –6 mmHg vs. –2 mmHg; p<0.05). Source: Yakuri to Chiryo (Pharmacology & Therapeutics), Vol.46, No.4, pp.529–537 (2018). This is a representative research review and not a clinical trial conducted using this specific product.
A Note on Evidence: We present research on ingredients, not specific product claims. Individual results may vary. This supplement is not intended to diagnose, treat, cure, or prevent any disease.
The Story
About Brand Story
FANCL Corporation
Expanding into supplements in 1994, FANCL helped popularize the "supplement" concept in Japan and now holds top market share in functional food supplements. The company operates its own research institute and manufacturing facilities, ensuring quality from development through production. Now part of the Kirin Holdings group, FANCL continues its mission of "Honest Quality" across beauty and wellness.
Our Curation Process
Why We Selected This Product
Every product at Naturacare undergoes rigorous evaluation before joining our collection.
信頼性
Brand Reliability
FANCL has operated on a no-additive manufacturing philosophy since 1980, formulating products without unnecessary preservatives or fillers. That discipline, combined with decades of Japanese consumer trust and transparent ingredient sourcing, was a primary reason we chose to carry this product.
精確性
Precise Targeting
Unlike broad wellness supplements, Blood Pressure Support is formulated specifically for adults with high-normal blood pressure, using ingredients dosed exactly to match the parameters established in peer-reviewed clinical trials — not generalized wellness claims.
科学的根拠
Scientific Evidence
The combination of Tripeptide MKP and GABA in a single functional food is backed by a peer-reviewed RCT published in Nutrients (2024) and multiple supporting studies — a level of clinical substantiation that is rare among over-the-counter supplement products.
Our Promise: We don't just import popular Japanese supplements - we investigate each product's formulation, manufacturing standards, and real-world reputation in Japan.
Every bottle of FANCL Blood Pressure Support sold at Naturacare is sourced directly from authorized Japanese channels. FANCL manufactures under Japan's Food with Functional Claims (機能性表示食品) framework, with scientific substantiation reviewed by the Consumer Affairs Agency. We carry this product because the evidence genuinely supports it. Our recommendation reflects the research — not commercial incentive.
Why Japan
The Japanese Advantage
Japan's supplement industry operates under some of the world's strictest quality standards. Combined with a cultural dedication to craftsmanship and centuries of wellness traditions, Japanese supplements represent a level of quality that's difficult to find elsewhere.
Rigorous Quality Standards
Japanese regulations require comprehensive testing at every stage of production, with standards that often exceed international requirements.
GMP-Certified Manufacturing
All our products come from facilities that meet Japan's strict GMP (Good Manufacturing Practice) certification requirements.
Centuries of Tradition
Many Japanese supplements draw on ingredients and formulations refined over generations, combining ancient wisdom with modern science.
Transparent Sourcing
Japanese manufacturers maintain complete traceability, so you know exactly where every ingredient comes from.
Directions
How to Use
Simple daily routine for optimal results.
Tips for Best Results
- Swallow the tablets whole with a full glass of water; do not crush, split, or chew the coated tablets.
- Allow at least 4 weeks before assessing early changes; the full clinical timeframe for evidence-based evaluation is 12 weeks of continuous daily use.
- Pair with a reduced-sodium diet — aim for under 6 g of salt (sodium chloride) per day — to support the body's blood pressure regulatory mechanisms.
- Incorporate regular light aerobic activity, such as 30-minute brisk walks five days per week, for a compounding lifestyle benefit alongside supplementation.
- Store the supplement in a cool, dry location away from direct sunlight and humidity; avoid bathroom cabinets where temperature and moisture fluctuate.
- f you are taking prescription blood pressure medications or have been formally diagnosed with hypertension, discuss this supplement with your physician before starting.
What's Inside
Ingredients
A minimal, no-additive formula built around two clinically studied active ingredients — Tripeptide MKP and GABA — with only essential excipients required for tablet integrity and shelf stability.
Tripeptide MKP (Methionine-Lysine-Proline)
A bioactive peptide derived from casein (bovine milk protein) via enzymatic hydrolysis and sourced from Morinaga Milk Industry's MKP® ingredient, manufactured in New Zealand. Tripeptide MKP inhibits angiotensin-converting enzyme (ACE), reducing vasoconstriction and supporting lower blood pressure through a mechanistically validated pathway.
GABA (γ-Aminobutyric Acid)
A naturally occurring amino acid that acts on peripheral sympathetic nerve terminals to reduce noradrenaline release, promoting vasodilation and autonomic nervous system balance. GABA's blood pressure-supporting role is documented in multiple clinical studies and complements MKP's ACE-inhibitory mechanism via a distinct physiological route.
Shellac (Tablet Coating)
A natural resin used as a thin coating to protect tablet integrity during shelf life. No colorants, preservatives, or flavor enhancers are present. Cellulose, calcium stearate, and colloidal silicon dioxide serve as binder, lubricant, and flow agent respectively — consistent with FANCL's no-additive manufacturing standard.
Ingredients: Milk protein peptide (contains milk, manufactured in New Zealand), gamma-aminobutyric acid (GABA) / cellulose, calcium stearate, colloidal silicon dioxide, shellac
Allergen Information: Milk (乳) — present in the milk protein peptide raw material
Important Information
Safety & Precautions
Please read before use.
Allergies
Not suitable for those with allergies to shrimp, crab, egg, or milk products. Check the full ingredient list if you have other food allergies.
Pregnancy & Nursing
Not recommended for pregnant or nursing women. Consult your healthcare provider before use.
Children
Not intended for children. Keep out of reach of infants and young children.
Medications
If you take prescription medications, consult your doctor before starting this supplement.
Dosage
Do not exceed the recommended daily amount of 3 tablets. Take as directed.
Storage
Store in a cool, dry place away from direct sunlight and high humidity. Refrigeration is recommended to preserve the live Bifidobacterium bacteria. Close the resealable package tightly after use.
Handling
Do not touch tablets with wet hands. Handle hygienically. Consume promptly after opening.
Disclaimer
This is a Functional Food, not a medicine. It supports wellness but does not treat, cure, or prevent any disease. Maintain a balanced diet as the foundation of healthy eating.
Details
Product Specifications
Questions