Key Takeaways
Premium Cartilage Components
Contains non-denatured Proteoglycan and Type II Collagen from Hokkaido salmon nasal cartilage - the actual structural components of cartilage, not just building blocks like glucosamine.
Simple Daily Routine
Take 3 tablets daily with water. One bag provides approximately one month's supply of 93 tablets for convenient daily joint support.
Quality Assured
Manufactured in a GMP-certified facility in Japan (Certification #11105). Monde Selection Gold Award winner for 4 consecutive years (2018-2021).
Hokkaido Heritage
Sourced from wild salmon caught in Hokkaido coastal waters. Carefully extracted without heat to preserve the natural, non-denatured form of cartilage components.
Best For
Those experiencing joint discomfort during daily activities like climbing stairs, walking, standing up, or sitting in seiza position who want comprehensive joint support.
Trusted in Japan
Over 4 million bags sold since launch. Approximately 70% of users report feeling results within 3 months of consistent use. 91% customer satisfaction rate.
Is This Right For You?
Recommended For
Kitaguni no Megumi proteoglycan supplement is designed for those seeking natural joint support with premium Japanese-sourced cartilage components.
If you're experiencing discomfort when climbing stairs or walking on inclines and want natural joint support
If you've tried glucosamine or chondroitin supplements but haven't felt the results you were hoping for
If you're noticing your joints becoming less comfortable during everyday activities like sitting down or standing up
If you want to stay active and mobile well into your senior years without letting joint concerns slow you down
If you're looking for a joint supplement that provides the actual cartilage components rather than just the building blocks
If you value Japanese quality manufacturing and want a supplement trusted by millions of Japanese consumers
If you're seeking a comprehensive joint support formula that includes both cartilage and muscle support ingredients
If you want to continue enjoying activities like hiking, swimming, or playing with grandchildren without joint worries
Why It Works
Benefits
Kitaguni no Megumi delivers comprehensive joint support through carefully selected cartilage and muscle components.
Supports Joint Comfort & Cushioning
Proteoglycan is a key cartilage component with exceptional water-retention properties, helping maintain the cushioning function of joints. Unlike glucosamine or chondroitin which are merely parts of proteoglycan, this supplement provides the complete, intact cartilage component in its natural non-denatured form for optimal joint comfort support.
Cartilage component researchMaintains Cartilage Structure
Type II Collagen makes up approximately 75% of cartilage (excluding water) and serves as the foundation that holds cartilage together. Kitaguni no Megumi uses non-denatured Type II Collagen extracted without heat, preserving its natural triple-helix structure so your body can recognize and utilize it effectively.
Research-backed ingredientComprehensive Cartilage Support
Together, Proteoglycan, Type II Collagen, and Hyaluronic Acid comprise about 95% of cartilage components. This supplement provides all three in one formula, offering more comprehensive joint support than supplements that focus on just one or two components.
Multi-component formulaSupports Active Mobility
Includes Imidazole Dipeptide from chicken extract - the muscle component found abundantly in migratory birds that enables them to fly up to 10,000km without rest. This ingredient supports not just your joints but also the muscles that support them during activities like climbing stairs, walking slopes, or doing squats.
Muscle support ingredientThe Science
How It Works
Understanding how Kitaguni no Megumi supports your body's natural joint health.
Non-Denatured Proteoglycan: The Cushion Component
Key points:
- Glucosamine and chondroitin are just parts that make up proteoglycan
- Kitaguni no Megumi provides intact proteoglycan from Hokkaido salmon
- Extracted without heat to preserve the non-denatured form
Non-Denatured Type II Collagen: The Foundation
Key points:
- Serves as the structural foundation that holds cartilage together
- Retains nutrients in cartilage tissue
- Non-denatured extraction preserves its natural triple-helix structure
The 95% Cartilage Component Advantage
Rather than providing just the building blocks like glucosamine, Kitaguni no Megumi delivers the actual structural components of cartilage through proprietary cold-extraction technology.
The Science
Research & Evidence
What science tells us about the key ingredients in this proteoglycan supplement.
Cartilage Component Decline with Age—Research published in the Journal of Clinical Investigation and Maturitas shows that cartilage components decline significantly with age, particularly after age 40. This decline accelerates through the 60s and 80s.
Monde Selection Gold Award - 4 Consecutive Years—Kitaguni no Megumi received Monde Selection Gold Award for 4 consecutive years (2018, 2019, 2020, 2021), internationally recognizing its quality.
A Note on Evidence: We present research on ingredients, not specific product claims. Individual results may vary. This supplement is not intended to diagnose, treat, cure, or prevent any disease.
Ingredient Research Highlights
PROTEOGLYCAN
Proteoglycan is a cartilage-specific component with unique water-retention properties. Research indicates it plays a crucial role in maintaining the cushioning function of joints.
Cartilage biology researchTYPE II COLLAGEN
Type II Collagen is the primary structural protein in cartilage, comprising about 75% of cartilage dry weight. Studies suggest that non-denatured Type II Collagen may be more effectively utilized by the body.
Collagen research, nutritional scienceIMIDAZOLE DIPEPTIDE
Imidazole dipeptides (carnosine and anserine) are found in high concentrations in animal muscles, particularly in species requiring sustained activity. Research has explored their potential role in supporting muscle function.
Amino acid metabolism researchThe Story
About Brand Story
Wellvenus Co., Ltd.
The company has earned Monde Selection Grand Gold Awards for four consecutive years and recognition as the top doctor-recommended cartilage supplement in Japan. Committed to delivering premium quality at accessible prices, Wellvenus continues to achieve consistent revenue growth since its founding.
Our Curation Process
Why We Selected This Product
Every product at Naturacare undergoes rigorous evaluation before joining our collection.
革新性
Innovation
While glucosamine and chondroitin are commonly found in joint supplements, Kitaguni no Megumi takes a different approach by providing the actual cartilage components - Proteoglycan and Type II Collagen - in their natural, non-denatured form using proprietary cold-extraction technology.
品質
Quality Assurance
Manufactured in a GMP-certified facility in Japan with internationally recognized quality, evidenced by 4 consecutive Monde Selection Gold Awards. Uses premium Hokkaido salmon as the source material.
実績
Proven Track Record
Over 4 million bags sold demonstrates strong market validation in Japan. The 91% customer satisfaction rate and testimonials from active seniors who've regained mobility speak to real-world effectiveness.
Our Promise: We don't just import popular Japanese supplements - we investigate each product's formulation, manufacturing standards, and real-world reputation in Japan.
We selected Kitaguni no Megumi because it represents a thoughtful evolution in joint support - moving beyond basic building blocks to provide the actual structural components of cartilage.
Why Japan
The Japanese Advantage
Japan's supplement industry operates under some of the world's strictest quality standards. Combined with a cultural dedication to craftsmanship and centuries of wellness traditions, Japanese supplements represent a level of quality that's difficult to find elsewhere.
Rigorous Quality Standards
Japanese regulations require comprehensive testing at every stage of production, with standards that often exceed international requirements.
GMP-Certified Manufacturing
All our products come from facilities that meet Japan's strict GMP (Good Manufacturing Practice) certification requirements.
Centuries of Tradition
Many Japanese supplements draw on ingredients and formulations refined over generations, combining ancient wisdom with modern science.
Transparent Sourcing
Japanese manufacturers maintain complete traceability, so you know exactly where every ingredient comes from.
Directions
How to Use
Simple daily routine for optimal joint support.
You can take them all at once or split throughout the day based on your preference.
Consistency is key - daily use helps maintain steady levels of cartilage-supporting nutrients in your body.
Tips for Best Results
- Take consistently at the same time daily to build a routine
- Allow at least 2-3 months of consistent use before evaluating results - 70% of users feel effects within 3 months
- Stay active with appropriate exercise to complement supplementation
- Store in a cool, dry place away from direct sunlight and high humidity
- Keep out of reach of children
- Can be taken with other supplements unless otherwise directed by your healthcare provider
What's Inside
Ingredients
Transparent formulation featuring premium Hokkaido-sourced cartilage components.
Non-Denatured Proteoglycan
Cartilage cushioning component with high water-retention from Hokkaido salmon nasal cartilage
Non-Denatured Type II Collagen
Cartilage structural foundation comprising 75% of cartilage (excluding water)
Imidazole Dipeptide
Muscle support component from chicken extract for joint-muscle synergy
Ingredients: Reduced maltose syrup (Manufactured in Japan), Dextrin, Boswellia serrata resin extract, Cat's claw extract, Salmon nasal cartilage extract, Chicken extract, Brewer's yeast (containing Selenium), White willow extract / Cellulose, Calcium stearate, Fine silicon dioxide, Vitamin E extract, Vitamin B1, Vitamin B6, Vitamin D, Vitamin B12.
Allergen Information: Does NOT contain: 7 major allergens (egg, milk, wheat, shrimp, crab, peanut, buckwheat). Contains: Salmon (fish), Chicken. Note: Those with plant allergies should review the full ingredient list.
Important Information
Safety & Precautions
Please read before use.
Allergies
Does not contain the 7 major Japanese allergens (egg, milk, wheat, shrimp, crab, peanut, buckwheat). Contains salmon and chicken. Those with plant allergies should review the full ingredient list before use.
Pregnancy & Nursing
Consult your healthcare provider before use if you are pregnant, nursing, or planning to become pregnant.
Medications
If you take prescription medications, consult your doctor before starting this supplement. You may show them the ingredient list included with the product.
Dosage
The recommended amount is approximately 3 tablets per day. This is a guideline amount. Do not significantly exceed the recommended daily amount.
Discontinue Use
If you experience any adverse effects, discontinue use and consult a healthcare professional.
Disclaimer
This is a dietary supplement, not a medicine. It supports wellness but does not treat, cure, or prevent any disease.
Storage
Keep in a cool, dry place away from direct sunlight and high humidity. Keep out of reach of infants and pets. Shelf life is 2 years from manufacture date.
Details
Product Specifications
Questions
Frequently Asked Questions
Think of it this way: glucosamine and chondroitin are building blocks, but proteoglycan is the complete structure your cartilage actually needs. This proteoglycan supplement provides the intact, non-denatured component directly.
Kitaguni no Megumi contains non-denatured Proteoglycan and Type II Collagen - comprising about 90% of cartilage structure. Also consider quality certifications (GMP manufacturing), proven track record, and extraction methods that preserve ingredient integrity.
Japan's strict quality standards (GMP certification) and innovation in cold-extraction technology help preserve the non-denatured form of these delicate cartilage components.
With age, proteoglycan levels decline, which is why supplementation can help maintain joint comfort and support daily activities like walking, climbing stairs, and staying active.
However, we recommend starting with the standard amount and adjusting based on your individual response. Do not significantly exceed reasonable amounts, and consult a healthcare provider if you have specific health concerns.
However, if you take prescription medications, we recommend consulting your doctor before starting. You can show them the ingredient list. Many customers take this alongside other joint or general health supplements.
Some notice improvements within 2 weeks to 1 month, while others take longer. The key is daily, consistent use - we recommend at least 3 months before evaluating effectiveness.
However, it does contain salmon (fish) and chicken extract. Those with plant allergies should review the full ingredient list, as the product contains various plant-derived extracts.