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Kobayashi Pharmaceutical Co., Ltd.

Naitmin: Japanese Sleep Aid Not Melatonin for Deeper, Restful Sleep

Naitmin: Japanese Sleep Aid Not Melatonin for Deeper, Restful Sleep

A natural sleep aid not melatonin, Naitmin contains crocetin from gardenia fruit to reduce middle-of-night awakenings, deepen sleep, and ease morning fatigue. Japan's first functional food for age-related sleep decline.

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Key Takeaways

Crocetin-Powered Formula

Contains 7.5mg of crocetin, a rare carotenoid from gardenia fruit (only 0.4% of dried fruit) that supports quality sleep without relying on melatonin or sedatives.

Simple Once-Daily Routine

Take just 1 softgel capsule after dinner. The easy-to-swallow capsule makes consistent daily use effortless for long-term sleep support.

Quality & Safety Assured

Manufactured by Kobayashi Pharmaceutical in Japan. Free from artificial colors, flavors, and preservatives. Contains vitamins B1, B2, D, and E.

Japan's First of Its Kind

The first functional food in Japan registered (F454) specifically for addressing age-related decline in sleep quality, backed by clinical research.

Best For

Adults experiencing middle-of-night awakenings, shallow sleep, or morning fatigue due to aging. Ideal for those seeking a non-melatonin solution.

Clinically Validated

Research shows crocetin reduces nocturnal awakenings, increases deep sleep stages, and decreases morning drowsiness after 2 weeks of use.

Why It Works

Benefits

Naitmin delivers sleep support through crocetin, a naturally-derived functional ingredient with clinically demonstrated benefits.

1

Reduces Middle-of-Night Awakenings

Crocetin has been clinically shown to reduce the frequency of nocturnal awakenings. By indirectly inhibiting histamine H1 receptors (a key wakefulness signal in the brain), crocetin helps you stay asleep longer without the grogginess associated with sedative sleep aids.

Clinically validated (Phytomedicine, 2010)
2

Supports Deeper Sleep Quality

Clinical research demonstrates that crocetin supplementation increases delta wave activity during deep sleep stages and enhances overall sleep architecture. This leads to more consolidated, restorative sleep cycles that help you wake feeling genuinely refreshed.

Research-backed ingredient
3

Eases Morning Fatigue & Drowsiness

Participants in clinical trials reported reduced feelings of fatigue and drowsiness upon waking after taking crocetin for 2 weeks. Unlike some sleep aids that leave you groggy, Naitmin supports natural sleep without morning side effects.

Consumer validated
4

Comprehensive Vitamin Support

Beyond crocetin, Naitmin includes vitamins B1 (10mg), B2 (12mg), D (20-71mcg), and E (50mg) to support energy metabolism, nervous system function, and overall wellness.

Nutritional Functional Food

The Science

How It Works

Understanding how Naitmin's crocetin supports your body's natural sleep processes.

Crocetin's Sleep Mechanism

Crocetin's Sleep Mechanism

Crocetin works by indirectly inhibiting histamine H1 receptors in the brain.

Histamine is a key wakefulness-promoting neurotransmitter. When histamine binds to its receptors, it promotes alertness and arousal.

Crocetin's indirect inhibition of this pathway helps reduce the brain's wakefulness signals, allowing for deeper, more sustained sleep without forcing sedation.
Three Key Benefits for Sleep

Three Key Benefits for Sleep

Clinical research on crocetin demonstrates three primary benefits:
  • Deepens sleep quality by supporting natural sleep architecture
  • Reduces morning drowsiness so you wake feeling alert
  • Eases morning fatigue for a more refreshed start to your day
Addressing Age-Related Sleep Decline

Addressing Age-Related Sleep Decline

Research shows that sleep quality naturally declines with age. Deep non-REM sleep decreases while light sleep increases, making middle-of-night awakenings more common.

Naitmin was specifically developed as the first functional food to address this age-related decline in sleep quality.

The Science

Research & Evidence

Clinical evidence supporting crocetin as a functional ingredient for sleep quality.

Clinical Trial Results

Clinical Trial Results—A randomized, placebo-controlled, double-blind crossover study with 25 adults (aged 25-59) showed the crocetin group had reduced nocturnal awakening frequency compared to placebo after 2 weeks of 7.5mg daily intake.

Age-Related Sleep Pattern Changes

Age-Related Sleep Pattern Changes—Data from Japan's Ministry of Health showing how deep sleep decreases and light sleep increases with age, making middle-of-night awakenings more common.

A Note on Evidence: We present research on ingredients, not specific product claims. Individual results may vary. This supplement is not intended to diagnose, treat, cure, or prevent any disease.

Ingredient Research

CROCETIN

Crocetin is a carotenoid compound naturally found in gardenia fruit and saffron. Clinical research has demonstrated its potential to support quality sleep by reducing middle-of-night awakenings, enhancing deep sleep stages, and easing morning fatigue through indirect inhibition of histamine H1 receptors.

Phytomedicine, 17, 840-843, 2010

About Brand Story

Kobayashi Pharmaceutical Co., Ltd.

Kobayashi Pharmaceutical Co., Ltd.

Kobayashi Pharmaceutical Co., Ltd. — founded in 1886 in Nagoya and now headquartered in Osaka — is one of Japan's most innovative healthcare companies. Famous for its slogan "Making 'if only there were such a thing' a reality," the company excels at identifying unmet consumer needs and developing unique solutions.

With over 150 brands spanning OTC pharmaceuticals, supplements, oral care, and household products, Kobayashi is known for iconic products like Netsusama Sheet cooling pads, Inochi no Haha women's health supplements, and Bluelet toilet cleaners — all featuring distinctively descriptive Japanese product names.

Our Curation Process

Why We Selected This Product

Every product at Naturacare undergoes rigorous evaluation before joining our collection.

革新性

Innovation

Japan's first functional food registered specifically for age-related sleep quality decline. Naitmin represents a pioneering approach to sleep support that doesn't rely on melatonin or sedatives.

信頼性

Reliability

Backed by Kobayashi Pharmaceutical, a trusted Japanese healthcare company. The product carries functional food registration F454, meaning its claims have been reviewed and accepted by Japan's Consumer Affairs Agency.

自然

Natural Approach

Uses plant-derived crocetin from gardenia fruit rather than synthetic compounds or hormones. Free from artificial colors, flavors, and preservatives, aligning with our commitment to natural wellness solutions.

Our Promise: We don't just import popular Japanese supplements - we investigate each product's formulation, manufacturing standards, and real-world reputation in Japan.

Naitmin earned its place in our collection because it offers a genuinely different approach to sleep support. For customers seeking a sleep aid not melatonin, this crocetin-based formula provides clinically-backed benefits through a natural mechanism.

Why Japan

The Japanese Advantage

Japan's supplement industry operates under some of the world's strictest quality standards. Combined with a cultural dedication to craftsmanship and centuries of wellness traditions, Japanese supplements represent a level of quality that's difficult to find elsewhere.

Rigorous Quality Standards

Japanese regulations require comprehensive testing at every stage of production, with standards that often exceed international requirements.

GMP-Certified Manufacturing

All our products come from facilities that meet Japan's strict GMP (Good Manufacturing Practice) certification requirements.

Centuries of Tradition

Many Japanese supplements draw on ingredients and formulations refined over generations, combining ancient wisdom with modern science.

Transparent Sourcing

Japanese manufacturers maintain complete traceability, so you know exactly where every ingredient comes from.

Directions

How to Use

Simple once-daily routine for optimal sleep support.

Take 1 softgel capsule per day with water or warm liquid.

Consume after dinner in the evening for optimal effectiveness.

Swallow the capsule whole; do not chew or break open. Use consistently for at least 2-4 weeks to experience full benefits.

Do not exceed the recommended daily dosage of 1 capsule.

Tips for Best Results

  • Take consistently at the same time each evening after dinner
  • Do not exceed 1 capsule daily - the 7.5mg crocetin dosage is optimized for effectiveness
  • Maintain good sleep hygiene: consistent bedtime, dark room, limited screens before bed
  • Allow 2-4 weeks of consistent use for noticeable improvements in sleep quality
  • Store in a cool, dry place away from direct sunlight and humidity
  • Vitamin B2 may cause harmless yellowing of urine - this is normal and not a concern

What's Inside

Ingredients

Clean formula with a focused functional ingredient and supporting vitamins.

7.5mg

Crocetin

Carotenoid from gardenia fruit, functional ingredient

10.0mg

Vitamin B1

Supports energy metabolism

12.0mg

Vitamin B2

Supports energy metabolism

Ingredients: Gelatin (manufactured in Japan), vitamin E-containing vegetable oil, safflower oil, glycerin, vitamin B2, gardenia (source of crocetin), vitamin B1, glycerin fatty acid ester, phytic acid, vitamin D

Allergen Information: Contains: Gelatin. Free from: Fish, shellfish, eggs, milk, wheat, peanuts, soybeans, tree nuts, sesame.

Important Information

Safety & Precautions

Please read before use.

Allergies

Not suitable for individuals with allergies to gelatin or any ingredients listed. Carefully review the full ingredient list before consumption.

Age Restrictions

Not intended for infants, children, or adolescents under 18 years of age.

Pregnancy & Nursing

Not recommended for pregnant women, those planning pregnancy, or nursing mothers. This product was not developed for these populations.

Medications

If you have any medical conditions or are taking medications, consult your physician before use.

Dosage

Do not exceed the recommended daily dosage of 1 capsule. The 7.5mg crocetin amount is clinically optimized - taking more does not enhance benefits.

Discontinue Use

Discontinue use immediately and consult a doctor if you experience any adverse reactions.

Storage

Store in a cool, dry place away from direct sunlight and humidity. Keep out of reach of children.

Regulatory Information

This product is registered as a Food with Function Claims (届出番号: F454) with Japan's Consumer Affairs Agency. It has not undergone individual review by the Agency. This product is not intended to diagnose, treat, cure, or prevent any disease.

Details

Product Specifications

Product Name
Naitmin: Japanese Sleep Aid Not Melatonin for Deeper, Restful Sleep
Brand
Kobayashi Pharmaceutical Co., Ltd.
Contents
40 softgel capsules
Serving Size
1 capsule
Servings Per Container
40 servings (40-day supply)
Net Weight
320mg per capsule
Form
Softgel capsule
Country of Origin
Japan
Manufacturing
Kobayashi Pharmaceutical - Functional Food F454

Questions

Frequently Asked Questions

Naitmin uses crocetin, a plant-derived carotenoid from gardenia fruit, as its functional ingredient. Unlike melatonin (a hormone), crocetin works by indirectly inhibiting histamine receptors to support natural sleep without affecting your circadian rhythm or creating hormone dependency.

It's an effective sleep aid not melatonin for those seeking alternatives.
Both GABA and melatonin work differently. GABA promotes relaxation while melatonin affects your sleep-wake cycle. Naitmin takes a third approach using crocetin, which targets histamine pathways.

For those wanting to avoid both melatonin and GABA supplements, Naitmin offers a unique evidence-backed alternative.
Functional foods like Naitmin offer a gentle approach to sleep support. As a sleep aid not melatonin, Naitmin contains crocetin which has been clinically studied for safety and efficacy. It's non-habit forming and doesn't cause next-day grogginess.

However, consult your doctor if you have chronic insomnia.
Naitmin uses a Japanese herbal approach to sleep support rather than relying on melatonin hormones. Crocetin works by modulating histamine receptors, providing a more natural feeling of sleepiness without the hormonal approach.

Many find this sleep aid not melatonin gentler and less likely to cause morning grogginess.
Take Naitmin after dinner each evening. Clinical studies showed benefits after 2 weeks of consistent use.

Some people notice improvements in sleep quality within the first week, while others find the effects build over time with consistent daily use.
Naitmin is designed to support natural sleep without causing morning grogginess. Clinical research shows crocetin actually helps reduce morning drowsiness and fatigue.

Unlike stronger sleep medications or some melatonin supplements, Naitmin works with your body's sleep cycle rather than forcing sedation.
Naitmin uses natural crocetin and is designed for regular use without creating dependency. It's not a sedative or pharmaceutical sleep aid.

However, good sleep hygiene practices should also be maintained for best long-term results.
No, do not exceed one capsule daily. The 7.5mg crocetin dosage is clinically optimized for effectiveness.

Taking more does not enhance benefits and may result in unnecessary vitamin intake. Consistency over time is more important than higher doses.
Naturacare offers Naitmin, a Japanese sleep aid not melatonin, shipped directly to customers worldwide.

As a curated Japanese wellness retailer, we bring you authentic products from trusted manufacturers like Kobayashi Pharmaceutical that may not be readily available outside Japan.
Naitmin is designed for ongoing use to support sleep quality as you age. Its functional ingredient crocetin is plant-derived and the product has been registered as a functional food (F454) in Japan.

It contains no sedatives, no melatonin, and no habit-forming ingredients.