Kirin Holdings Company, Limited

Kirin iMUSE: Japanese Probiotic for Immune System Support

Contains 100 billion Plasma Lactobacillus (L. lactis strain Plasma) per serving, the world's first probiotic reported to activate pDC immune command cells, helping maintain healthy immune function.

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$43.98 USD

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Unique Probiotic Strain

Contains 100 billion Plasma Lactobacillus (L. lactis strain Plasma) per 4-tablet daily serving, a Kirin-discovered probiotic with immune support function.

Simple Daily Routine

Take 4 easy-to-swallow tablets once daily with water. No refrigeration needed, convenient for daily immune care at home or on the go.

Functional Labeled Food

Officially registered as a Functional Labeled Food with Japan's Consumer Affairs Agency, notification number G777, backed by scientific evidence.

Kirin's Immune Research Heritage

Developed by Kirin Holdings, drawing on decades of dedicated immune research to discover the Plasma Lactobacillus strain that activates immune command cells.

Best For

Those seeking a natural, research-backed Japanese probiotic for immune system maintenance during seasonal changes, busy lifestyles, or family health support.

Market Proven

Rakuten Daily Ranking #1 in Probiotics, No.1 in Japan's functional food immune supplement market, with a 93% repeat purchase rate.

If you're looking for a research-backed probiotic for immune system support that goes beyond general gut health

If you want to maintain your immune function during seasonal changes and want a convenient daily supplement

If you're a busy professional seeking a simple, once-daily immune care routine that fits into your schedule

If you value Japanese quality and want a probiotic immune support supplement from a trusted heritage brand

If you're health-conscious and prefer a functional labeled food with officially registered scientific evidence

If you want to support your family's health with a natural immune system supplement suitable for adults of all ages

If you've been searching for a lactobacillus probiotic that specifically targets immune function rather than just digestive health

If you're interested in probiotics from Japan and want a product backed by dedicated immune research from Kirin

1

Activates Immune Command Cells

Plasma Lactobacillus (L. lactis strain Plasma) works by targeting pDC (Plasmacytoid Dendritic Cells), known as the command center of the immune system. By activating pDC, it helps coordinate the body's broader immune response, supporting the maintenance of healthy immune function in a way that general lactic acid bacteria do not.

Clinically reported mechanism

2

Supports Daily Immune Maintenance

Consistent daily intake of Plasma Lactobacillus helps support the maintenance of immune function for healthy individuals. The official functional claim states that Plasma Lactobacillus works on pDC to help maintain immune function, making it suitable as a daily immune care habit alongside balanced nutrition and exercise.

Functional Labeled Food

3

Convenient Once-Daily Probiotic

Just 4 small tablets daily provide 100 billion Plasma Lactobacillus plus 500mg of isomaltooligosaccharides. At only 3.5 kcal per serving with no major allergens, this probiotic supplement for immune system support fits seamlessly into any daily routine without dietary concerns.

Allergen-free formula (28 items checked)

4

Backed by Kirin's Research

Kirin Holdings discovered the Plasma Lactobacillus strain through extensive immune research. It is the world's first lactobacillus reported to activate pDC in scientific literature. Clinical research demonstrated pDC activation after intake, published in peer-reviewed journals, supporting the functional claims of this Japanese probiotic.

Published clinical research

pDC Activation - Targeting the Immune Command Center

Unlike general lactic acid bacteria that interact with limited immune cells, Plasma Lactobacillus (L. lactis strain Plasma) directly activates pDC (Plasmacytoid Dendritic Cells), the command center of the immune system.

Once activated, pDC sends signals to coordinate multiple types of immune cells:

NK cells
Killer T cells
B cells
Helper T cells

This broad activation of the entire immune cell network is what makes Plasma Lactobacillus unique among probiotic strains.

Whole Immune Cell Network Activation

When pDC is activated by Plasma Lactobacillus, it triggers a cascade of immune cell activation throughout the body.

Rather than stimulating individual immune cells one at a time, this mechanism supports the coordinated activation of the entire immune cell network. This efficient approach to immune support is why Kirin describes it as activating the commander of immune cells, enabling the body's natural defenses to work in harmony.

Supporting Immune Maintenance Through Daily Habits

Maintaining immune function requires ongoing daily habits: adequate exercise, balanced nutrition, and sufficient rest.

Plasma Lactobacillus serves as an easy-to-add complement to these healthy lifestyle practices. As a heat-killed probiotic in tablet form, it does not require refrigeration and can be taken conveniently at any time of day.

pDC Activation Clinical Study—A clinical study examined the effect of Plasma Lactobacillus intake on pDC activation. Fifty-one male subjects who exercised regularly were divided into two groups: one receiving capsules containing 100 billion Plasma Lactobacillus and one receiving placebo capsules. After 2 weeks, the pDC activation marker (CD86) showed a statistically significant increase (at the 5% significance level) in the Plasma Lactobacillus group compared to the placebo group. Published in J Int Soc Sports Nutr. 15(1):39. Note: This is a representative study from the systematic review. This clinical study was not conducted using this specific product.

Rakuten #1 Ranking & Market Leader—Kirin iMUSE achieved Rakuten Daily Ranking #1 in the Probiotics category. It holds the No.1 position in Japan's functional food immune maintenance supplement market based on sales data from Fuji Keizai 2025 HB Foods Marketing Handbook. The product maintains a 93% repeat purchase rate and a 4.55 out of 5 review rating.

Expert Medical Endorsements—Endorsed by medical professionals including Dr. Tetsuya Matsumoto (International University of Health and Welfare, Infectious Disease Department), Dr. Yasuhiro Nishizaki (Tokai University, Health Management), and Dr. Toshio Miyata (Medical Compass CEO, Waseda University Professor). Experts highlight the scientific basis of Plasma Lactobacillus and recommend functional labeled foods with scientific evidence.

Consumer Reviews & Repeat Rate—The product maintains a 93% repeat purchase rate (measured from subscription starters between November 2020 and January 2023) and a 4.55 review rating (as of December 2024). Customer testimonials from users in their 50s and 60s highlight the convenience and peace of mind of daily immune care with Plasma Lactobacillus.

A Note on Evidence: We present research on ingredients, not specific product claims. Individual results may vary. This supplement is not intended to diagnose, treat, cure, or prevent any disease.

Ingredient Research Highlights

PLASMA LACTOBACILLUS (L. lactis strain Plasma)

Plasma Lactobacillus is the world's first lactic acid bacterium reported in scientific literature to activate human pDC (Plasmacytoid Dendritic Cells). Discovered by the Kirin Group, this unique strain supports the maintenance of healthy immune function by targeting the immune system's command cells.

PubMed and Igaku Chuo Zasshi WEB database search results

FUNCTIONAL LABELED FOOD REGISTRATION

iMUSE is registered as a Functional Labeled Food with Japan's Consumer Affairs Agency under notification number G777. The official functional claim states that Plasma Lactobacillus has been reported to help maintain immune function in healthy individuals by working on pDC.

Consumer Affairs Agency registration, official maker information

ISOMALTOOLIGOSACCHARIDE

Each daily serving contains 500mg of isomaltooligosaccharides, a prebiotic component that complements the probiotic Plasma Lactobacillus. Isomaltooligosaccharides are produced from starch and are domestically manufactured in Japan.

Official product ingredient information

The Story

About Brand Story

Kirin Holdings Company, Limited

Kirin Holdings Company, Limited — incorporated in 1907 with origins dating back to Japan's first public brewery in 1870 — is one of Japan's largest beverage and pharmaceutical conglomerates, listed on the Tokyo Stock Exchange Prime Market. The company leverages over 35 years of fermentation and biotechnology research across its beer, beverage, pharmaceutical, and health science divisions.

Their proprietary Lactococcus lactis strain Plasma is the world's first lactic acid bacteria scientifically proven to activate pDC immune cells. The iMUSE brand became Japan's first functional food approved for immune health claims, backed by extensive clinical research and trusted by healthcare professionals nationwide.

革新性

Innovation

Kirin's Plasma Lactobacillus is the world's first lactic acid bacterium reported to activate pDC immune command cells, representing a genuinely novel approach to immune support backed by published clinical research.

信頼性

Credibility

Registered as a Functional Labeled Food with Japan's Consumer Affairs Agency, manufactured by Kirin Holdings, and endorsed by multiple medical professionals. This product carries institutional credibility that few supplements can match.

実績

Proven Track Record

No.1 in Japan's functional food immune supplement market, Rakuten #1 ranking, 93% repeat rate, and 4.55 review score demonstrate genuine consumer trust earned over sustained market performance.

Our Promise: We don't just import popular Japanese supplements - we investigate each product's formulation, manufacturing standards, and real-world reputation in Japan.

We selected Kirin iMUSE because it represents the best of Japanese supplement innovation: a proprietary probiotic strain with a unique immune mechanism, backed by clinical evidence, regulatory approval, and overwhelming consumer validation in Japan's demanding market.

Japan's supplement industry operates under some of the world's strictest quality standards. Combined with a cultural dedication to craftsmanship and centuries of wellness traditions, Japanese supplements represent a level of quality that's difficult to find elsewhere.

Rigorous Quality Standards

Japanese regulations require comprehensive testing at every stage of production, with standards that often exceed international requirements.

GMP-Certified Manufacturing

All our products come from facilities that meet Japan's strict GMP (Good Manufacturing Practice) certification requirements.

Centuries of Tradition

Many Japanese supplements draw on ingredients and formulations refined over generations, combining ancient wisdom with modern science.

Transparent Sourcing

Japanese manufacturers maintain complete traceability, so you know exactly where every ingredient comes from.

Learn more

ake 4 tablets once daily with water.As a food product, there is no specific required timing. Choose a time that fits your routine to support consistent daily use.Immune function maintenance benefits from continuous, regular intake throughout the year.

Tips for Best Results

Take at the same time each day to build a consistent habit
Can be taken with or without food at your convenience
Pair with balanced nutrition, adequate exercise, and sufficient sleep for comprehensive immune support
Store with the zip lock firmly sealed after opening
Continue daily use throughout the year, not just during seasonal changes
Keep in a cool, dry place away from heat and direct sunlight

100 billion

Plasma Lactobacillus (L. lactis strain Plasma)

World's first pDC-activating probiotic strain, per 4-tablet daily serving

500mg

Isomaltooligosaccharide

Prebiotic that complements probiotic function, per 4-tablet daily serving

3.5 kcal

Per Serving Energy

Ultra-low calorie formula with only 0.9g carbohydrates per daily serving of 4 tablets

Ingredients: Isomaltooligosaccharide powder candy (domestically manufactured), Maltose, Heat-killed lactic acid bacteria powder / Cellulose, Calcium stearate

Allergen Information: Contains: None of the 28 designated allergen items. Free from: All 28 designated allergen items in Japan including milk, eggs, wheat, peanuts, and shellfish.

Allergies

This product does not contain any of the 28 designated allergen items in Japan. However, if you have specific food sensitivities, please review the full ingredient list before use.

Pregnancy & Nursing

This product was not developed for those with diseases, minors, pregnant women (including those planning pregnancy), or nursing mothers. Consult your healthcare provider before use.

Medications

If you are being treated for a medical condition, consult your physician. If you are taking pharmaceutical medications, consult your physician or pharmacist before use.

Dosage

The recommended daily intake is 4 tablets taken once daily. Excessive consumption does not enhance health benefits beyond the recommended amount.

Discontinue Use

If you experience any adverse changes in your physical condition, discontinue use immediately and consult a physician.

Disclaimer

This is a Functional Labeled Food, not a pharmaceutical product. It is not intended for the diagnosis, treatment, or prevention of disease. This product has been filed with Japan's Consumer Affairs Agency but has not been individually reviewed by the Agency.

Storage

After opening, firmly close the zip lock and consume promptly. Keep out of reach of infants and young children. Keep in a cool, dry place away from heat and direct sunlight.

Digestive Sensitivity

Excessive consumption or individual constitution may cause loose stools.

Product Name

iMUSE Immune Care Supplement 30-Day Supply

Brand

Kirin Holdings

Contents

120 tablets (250mg x 120)

Serving Size

4 tablets

Servings Per Container

30 servings

Net Weight

30g

Form

Tablet

Country of Origin

Japan

Manufacturing

Kirin Holdings (domestic manufacture)

What makes Plasma Lactobacillus different as a probiotic for immune system support?

Plasma Lactobacillus (L. lactis strain Plasma) is the world's first lactic acid bacterium reported to activate pDC (Plasmacytoid Dendritic Cells), the command center of the immune system.

While general probiotics may interact with limited immune cells, this strain supports the activation of the entire immune cell network through pDC, offering a unique mechanism for immune function maintenance.

How does this Japanese probiotic help maintain immune function?

Kirin iMUSE contains 100 billion Plasma Lactobacillus per daily serving. This probiotic strain works by activating pDC, which then coordinates multiple types of immune cells including NK cells, T cells, and B cells.

This mechanism has been reported in clinical research and supports the maintenance of healthy immune function when taken consistently.

When is the best time to take this lactobacillus tablet?

As a food product, iMUSE can be taken at any time of day. There is no specific required timing.

The official recommendation is to take 4 tablets once daily with water. Choose a time that works best for your schedule, as building a consistent daily habit is more important than specific timing for immune care.

Is this probiotic immune support supplement safe for daily use?

iMUSE is a registered Functional Labeled Food with Japan's Consumer Affairs Agency. It contains no allergens from the 28 designated items.

However, it was not developed for those with existing medical conditions, minors, or pregnant/nursing women. Consult your healthcare provider if you are taking medications or have health concerns.

How long should I take this lactobacillus probiotic to notice benefits?

Clinical research demonstrated pDC activation after 2 weeks of daily intake. However, immune function maintenance is an ongoing process.

The manufacturer recommends using iMUSE throughout the year as part of your daily health routine, not just during specific seasons. Consistent, long-term use alongside balanced nutrition and adequate exercise supports sustained immune maintenance.

What is pDC and why does it matter for immune system supplements?

pDC stands for Plasmacytoid Dendritic Cells, which function as the command center of the immune system. When activated, pDC coordinates the response of multiple immune cell types simultaneously.

Most probiotics interact with individual immune cells, but Plasma Lactobacillus targets pDC directly, enabling broader immune cell activation. This mechanism is what makes this natural immune system supplement unique.

Can I take this probiotic supplement with other medications or supplements?

iMUSE is a food product and is generally compatible with other supplements. However, if you are being treated for a medical condition or taking pharmaceutical medications, consult your physician or pharmacist before starting this supplement.

You may show them the ingredient list for their review.

Do people with dairy allergies need to worry about this lactobacillus capsule?

No. Despite containing lactic acid bacteria, iMUSE does not contain any dairy or milk ingredients. The product is free from all 28 designated allergen items in Japan, including milk.

This makes it suitable for those with dairy sensitivities who are looking for probiotic immune support without dairy-based concerns.

Where can I buy this Japanese probiotic supplement?

iMUSE Plasma Lactobacillus Immune Care Supplement is available through Naturacare.jp, which curates trusted Japanese health supplements for international customers.

We source directly from authorized channels to ensure authenticity. The 30-day supply is priced at $43.98 USD with international shipping available.

What is the difference between Functional Labeled Food and regular supplements?

Functional Labeled Foods are a Japanese regulatory category requiring companies to submit scientific evidence to the Consumer Affairs Agency before making health function claims.

Unlike general supplements, these products carry officially registered functional claims based on systematic literature reviews or clinical trials. iMUSE's notification number is G777, and its registered claim specifically addresses immune function maintenance.

Kirin iMUSE: Japanese Probiotic for Immune System Support